Your HFE C282Y and H63D genotype, explained in plain English.
Could it be haemochromatosis?
Symptoms that don't add up, bloods that look normal — one saliva test can tell you if the cause is genetic.
Always Led By Science.
Each DNA report has been researched and written by our in-house team of geneticists, medical doctors, and exercise physiologists.
Rather than following what's popular or relying on anecdotal evidence, we only consider peer-reviewed research in our reporting. Every individual insight and recommendation that you receive is underpinned by science.
Learn more about our science.
Does any of this sound familiar? Tap what applies to you.
Hereditary haemochromatosis is famously hard to spot because its symptoms look like everything else. Tick everything that resonates, then click Show my result for a personalised indication.
Hereditary haemochromatosis is famously hard to spot because its symptoms look like everything else. Take our 60-second symptom quiz — nine quick questions, no email needed — and we'll tell you whether your pattern is consistent with hereditary haemochromatosis and what the right next step is for you.
Tap above to start the guided symptom assessment.
My mum found out too late. I found out at 27.
It's the most common genetic disease you've never heard of. And it's hiding in plain sight.
Hereditary haemochromatosis causes the body to absorb too much iron from food. The iron has nowhere to go — so it slowly accumulates in the liver, joints, heart, and pancreas, often for decades before symptoms become severe enough to investigate.
The cruel irony: the gene variants behind it are well-understood, the test is simple, and the treatment is one of the most effective in modern medicine. The only thing missing is the diagnosis.
The two HFE gene variants behind 90%+ of hereditary cases.
From "could it be?" to a clear answer in four steps.
No clinic visits, no needles, no upfront referrals. Just spit, post, wait, and read.
Saliva kit posted free
Order online and we'll ship your collection kit within 24 hours, anywhere in the UK.
2ml of saliva, that's it
Spit into the tube, seal, drop it back in the prepaid envelope. Five minutes, kitchen counter.
EU-accredited lab
Your sample is processed in our ISO 17025 lab. We screen 600,000+ variants — including HFE.
Plain-English report
Your haemochromatosis insight unlocks in your app, alongside dozens of other DNA-led reports.
What you'll actually see in your report.
Clear, clinical-grade information — written so you can read it on the bus, not just hand it to a doctor.
You carry two copies of the C282Y mutation. This genotype is the primary genetic cause of type 1 hereditary haemochromatosis.
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Your exact HFE genotype
Zygosity for HFE C282Y and H63D — the two variants clinically relevant to hereditary haemochromatosis.
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What it means in plain English
Each combination explained simply — what's elevated, what's reassuring, and what's truly nothing to worry about.
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The exact tests to ask your GP for
If your result is elevated, we hand you a one-page summary you can take to your GP — including the specific blood markers (serum ferritin, transferrin saturation) that confirm a clinical diagnosis.
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Lifestyle levers that actually move the needle
Iron-aware nutrition, supplement caution (vitamin C, raw shellfish), and the role of regular blood donation — written as guidance, not gospel.
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Full access to BASIL & every workout plan
Every test includes our BASIL longevity analysis & recommendations system, plus unlimited access to all FitnessGenes workout plans — at no extra cost.
Iron damage is silent — until suddenly it isn't.
This is what makes haemochromatosis cruel: by the time it announces itself loudly, the damage is often already done. The opposite is also true — when you catch it early, you can live a completely normal life.
Vague symptoms, normal bloods
Tiredness, brain fog, the odd ache. Routine bloodwork looks fine. The body is quietly absorbing more iron than it can use, but ferritin sits within range.
Iron load crosses the threshold
Joint pain becomes harder to dismiss. Skin tone shifts. Sleep, mood, and libido change. Liver enzymes start to drift up — but rarely enough to alarm a busy GP.
Damage that doesn't fully reverse
By the time haemochromatosis is finally diagnosed in symptomatic patients, many already have cirrhosis, cardiomyopathy, or diabetes. The DNA test is the one thing that can intercept this.
Two ways to access your HFE genotype.
Whether you're new to DNA testing or already have data from another provider, you'll receive the same haemochromatosis report alongside 180+ further FitnessGenes reports.
For first-time DNA decoders
Non-invasive saliva collection kit, processed in our EU-accredited laboratory.
- Saliva collection kit, posted to your door
- HFE C282Y & H63D zygosity report
- 180+ further DNA reports across 14 categories
- Personalised nutrition, fitness & supplement guidance
- GP handover summary for elevated results
- Lifetime access to new report releases
For existing DNA data holders
Already have raw DNA data? Upload it and unlock your reports in minutes — no kit, no waiting.
- Upload from 23andMe, Ancestry.com or MyHeritage
- HFE C282Y & H63D zygosity report
- 180+ further DNA reports across 14 categories
- Personalised nutrition, fitness & supplement guidance
- GP handover summary for elevated results
- Lifetime access to new report releases
The fair questions everyone asks first.
Identify your HFE genotype once.
Hereditary haemochromatosis is highly manageable when identified early. A single DNA test reports your zygosity for the two clinically-relevant HFE variants — information that does not change.
This is genetic information, not a clinical diagnosis. An elevated genetic-risk result for hereditary haemochromatosis indicates the need for follow-up clinical testing (typically serum ferritin and transferrin saturation) with a qualified healthcare professional. Do not start, stop, or change any medical treatment based on a DNA test alone. If you have any symptoms that concern you, please speak to your GP.